5,5-Dimethyloxazolin-2-one → HCID 58484737, compound

HRID 1804415Notes

Reaction equation

HRID 1804415 reaction equation
[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:10]=2[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH:31]4[CH2:33][CH2:32]4)=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])[C:5]1=[O:34])(=[O:3])[CH3:2].[CH3:35][C:36]1([CH3:42])[O:40][C:39](=[O:41])[N:38]=[CH:37]1>>[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([N:38]3[CH2:37][C:36]([CH3:42])([CH3:35])[O:40][C:39]3=[O:41])[CH:12]=[CH:11][C:10]=2[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH:31]4[CH2:33][CH2:32]4)=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])[C:5]1=[O:34])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 214647825,5-Dimethyloxazolin-2-oneHCID 58484546HCID 58484546, compound

Product 1

HCID 58484737HCID 58484737, compoundYield 23.4%

Procedure

By reaction and treatment in the same manner as in Example 201 and using 1-acetyl-3-{5-chloro-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one (336 mg) described in Preparation Example 196 and 5,5-dimethyloxazolin-2-one (80.3 mg) described in Preparation Example 43, the title compound (91.3 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 201
  2. customdescribed in Preparation Example 43

Sources & evidence

ORD record
ord-84ebd7273c7b4a65ad897a8c7f1ec144
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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