HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → Methyl 4-[4-[([1,1'-biphenyl]-2-ylcarbonyl)amino]phenyl]-alpha-phenyl-1-piperazineacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Benzeneacetic acid, alpha-bromo-, methyl ester | HCID 137806 | — |
| Reactant | N-[4-(1-piperazinyl)phenyl]-[1,1'-biphenyl]-2-carboxamide | HCID 22499369 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 4-[4-[([1,1'-biphenyl]-2-ylcarbonyl)amino]phenyl]-alpha-phenyl-1-piperazineacetate | HCID 22499399 | 85.3% |
Reaction Steps
Methyl α-bromo-α-phenylacetate (0.1 mole) was added dropwise to a stirring mixture of intermediate (10) (0.07 mole) and Na2CO3 (13 g) in DMF (300 ml). The mixture was stirred overnight. The solvent was evaporated. The residue was crystallized from methanol. The precipitate was filtered off and dried, yielding 30.2 g of methyl 4-[4-[([1,1′-biphenyl]-2-ylcarbonyl)amino]phenyl]-α-phenyl-1-piperazineacetate (melting point 125° C.) identified as compound No. 52 in the following table F-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354402B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-9a56f5782fe144caa4993f2f9cb901b6 |
| Source note | uspto-grants-2013_01 |