HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(Propan-2-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Bromo-3-isopropylbenzene | HCID 138499 | — |
| Reactant | HCID 178418260 | HCID 178418260 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-(Propan-2-yl)benzonitrile | HCID 258440 | — |
Reaction Steps
5.15 g (25.87 mmol) m-bromo-isopropyl-benzene and 2.69 g (30.04 mmol) copper cyanide are stirred in 2.50 ml of pyridine for 24 hours at 180° C. Then 15 ml of water, 15 ml of toluene and 15 ml conc. ammonia solution are added, then the mixture is extracted. The organic phase is dried and evaporated to dryness.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354418B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-656f53ae722d463c8e6a0eff14f36527 |
| Source note | uspto-grants-2013_01 |