Potassium Hydroxide → 3-(2-oxo-imidazolidin-1-yl)-benzonitrile

HRID 1804543Notes

Reaction equation

HRID 1804543 reaction equation
Cl[CH2:2][CH2:3][NH:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]#[N:15])[CH:9]=1)=[O:6].[OH-].[K+]>C(O)C>[O:6]=[C:5]1[NH:4][CH2:3][CH2:2][N:7]1[C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=1)[C:14]#[N:15]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 11736224HCID 11736224, compound

Product 1

HCID 114581363-(2-oxo-imidazolidin-1-yl)-benzonitrile

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

110.00 g (490 mmol) 1-(2-chloro-ethyl)-3-(3-cyano-phenyl)-urea are dissolved in 2000 ml of ethanol at 50° C. and a solution of 42.00 g (640 mmol) potassium hydroxide in 390 ml of ethanol is added within 1.5 hours. The reaction mixture is stirred for 16 hours at ambient temperature, then the precipitate formed is suction filtered, washed with water and dried.

Workup

  1. customthe precipitate formed
  2. filtrationfiltered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-11c7c62c2f054b609d970bfa20080a3c
Source dataset
uspto-grants-2013_01
Patent number
US08354418B2

Reaction notes

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