HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(dimethylaminomethyl)benzonitrile → 1-[3-(Aminomethyl)phenyl]-N,N-dimethylmethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(dimethylaminomethyl)benzonitrile | HCID 4641088 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 1-[3-(Aminomethyl)phenyl]-N,N-dimethylmethanamine | HCID 16228070 | — |
Reaction Steps
7.00 g (34.95 mmol) 3-dimethylaminomethyl-benzonitrile are placed in 100 ml of methanolic ammonia solution and hydrogenated with 1.40 g Raney nickel at ambient temperature under a pressure of 3 bar. The catalyst is suction filtered, the filtrate is evaporated down. The residue is purified by chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354418B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-cc3e026be93e4d69bbb85eddd8afeb61 |
| Source note | uspto-grants-2013_01 |