HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804550Generated: October 31, 2026
1,1'-Carbonyldiimidazole → 5H,6H,7H,8H-imidazo(1,5-c)pyrimidin-5-one
https://huagongshe.com/reaction/1804550
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | HCID 178419017 | HCID 178419017 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5H,6H,7H,8H-imidazo(1,5-c)pyrimidin-5-one | HCID 1487518 | — |
Reaction Steps
50.00 g (450 mmol) histamine are dissolved in 1500 ml dimethylformamide, 73.87 g (450 mmol) carbonyldiimidazole are added. The reaction mixture is stirred for 5 hours at 70° C. and for 16 hours at ambient temperature. Then it is evaporated down, and the residue is extracted hot from acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08354418B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-1f77fd769f154b448e92726d1d24c1b2 |
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| Source note | uspto-grants-2013_01 |
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