HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl 5-(1H-tetrazol-1-yl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate → 5-(1H-tetrazol-1-yl)-octahydrocyclopenta[c]pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl 5-(1H-tetrazol-1-yl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate | HCID 67972161 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(1H-tetrazol-1-yl)-octahydrocyclopenta[c]pyrrole | HCID 67972121 | 92% |
Reaction Steps
The title compound from Step A above (670 mg, 2.4 mmol) was dissolved in 4 M HCl in dioxane (5 mL) and stirred at RT overnight. The product was concentrated under reduced pressure and dried under high vacuum to afford the title compound (i-38) (395 mg, 92%). EST-MS calculated for C8H13N5: Exact Mass: 179.09. Found 180.05.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354403B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-7fafa6c56d8242eba102009b65bdff77 |
| Source note | uspto-grants-2013_01 |