2-Pyridinecarboxaldehyde → HCID 67986523, compound

Participants

Reaction Steps

To a stirred solution of 1.50 mL (15.7 mmol) of pyridine-2-carbaldehyde in 70 mL of benzene under an atmosphere of nitrogen was added 2.92 g (15.7 mmol) of tert-butyl 1-piperazine-carboxylate followed by 1.87 g (15.7 mmol) of 1H-benzotriazole. The reaction mixture was heated to reflux for 3 h employing a Dean-Stark® Trap. The resulting mixture was cooled to ambient temperature and all volatiles were removed in vacuo to afford the title compound (i-78).

Provenance & Evidence