Methanesulfonyl chloride → HCID 12012457, compound

Participants

Reaction Steps

To a stirred solution of 0.27 g (2.2 mmol) of commercially available (1R)-1-pyridin-2-ylethanol in 5 mL of anhydrous dichloromethane was added 0.53 g (4.3 mmol) of 4-(dimethylamino)pyridine followed by 0.20 mL (2.6 mmol) of methanesulfonyl chloride. The resulting mixture was stirred with gradual warming to ambient temperature over 1 h. The resulting mixture was quenched with water and extracted with dichloromethane. The combined organics were washed with brine, dried over magnesium sulfate, filtered and evaporated to dryness to afford the title compound as a yellow oil (0.35 g, 81% yield).

Provenance & Evidence