HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (R)-phenyl[(2R,5S)-5-(4-{[10-(pyridin-2-ylmethyl)-9,10-diazatricyclo[4.2.1.12,5]dec-9-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Tert-butyl (2R,5S)-2-[(R)-hydroxy(phenyl)methyl]-5-(4-{[10-(pyridin-2-ylmethyl)-9,10-diazatricyclo[4.2.1.12,5]dec-9-yl]carbonyl}benzyl)pyrrolidine-1-carboxylate | HCID 67986715 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-phenyl[(2R,5S)-5-(4-{[10-(pyridin-2-ylmethyl)-9,10-diazatricyclo[4.2.1.12,5]dec-9-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol | HCID 67972072 | — |
Reaction Steps
The title compound from Step C above (30 mg, 0.06 mmol was dissolved in 4 M HCl in dioxane plus 10% water (v/v) (2 mL) and stirred at RT for 2 h. The mixture was concentrated under reduced pressure and dried under high vacuum to give the title compound. ESI-MS calculated for both is C33H36N4O2: Exact Mass: 522.32. Found 523.30.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354403B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-d77f1f8b5d7541dca33d9bc2c7d5496f |
| Source note | uspto-grants-2013_01 |