Methanesulfonyl chloride → HCID 12012457, compound

Participants

Reaction Steps

To a solution of (1R)-1-pyridin-2-ylethanol (250 mg, 2.03 mmol) and DMAP (496 mg, 4.06 mmol) in DCM (8 mL) was added MsCl (190 μL, 2.44 mmol) at 0° C. The mixture was stirred for 10 min at the same temperature and for an additional hour at RT. The mixture was quenched with ice water and extracted with ethyl acetate (2×15 mL). The organic layer was washed with water and brine, dried over sodium sulfate, filtered, and concentrated under vacuum. The residue oil was purified via prep-plate purification (1000 μM) eluting with 60% ethyl acetate in hexane to afford the product (310 mg, 76%).

Provenance & Evidence