HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzimidazole → Diisopropylethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzimidazole | HCID 5798 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Diisopropylethylamine | HCID 81531 | — |
Reaction Steps
The benzimidazole is formed by coupling the diamino compound with the appropriate carboxylic acid, preactivated carboxylic acid, mixed anhydride or anhydride in solvents such as THF, DMF or DCM and in the presence of a base such as TEA or DIPEA to form the corresponding amide. The amide is than treated with an acid at 40-80° C. for 2-24 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354419B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-5840c29091c14ae581d8f866ebfbfeb9 |
| Source note | uspto-grants-2013_01 |