Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2486-69-3 | HCID 288057 | — |
| Reactant | 2-chloro-5-fluoro-N-methylpyrimidin-4-amine | HCID 5072307 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58539164 | HCID 58539164 | 88.4% |
Reaction Steps
A mixture of 50 mg 2-chloro-5-fluoro-N-methylpyrimidin-4-amine, 57 mg 4-Amino-3-methoxybenzoic acid, 0.1 mL 4N HCl in 1,4-dioxane and 1 mL N-butanol was placed in a 10 mL snap-top microwave vial (CEM Corp.) and heated to 120° C. microwave for 40 min. The reaction was monitored by LC/MS. The precipitated solid was filtered to yield 80 mg of 4-(5-fluoro-4-(methylamino)pyrimidin-2-ylamino)-3-methoxybenzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08354420B2 |
|---|
| Source dataset | uspto-grants-2013_01 |
|---|
| ORD ID | ord-3692ae146a20452caae1aad42065a5cc |
|---|
| Source note | uspto-grants-2013_01 |
|---|
