HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Methyl-4-(piperidin-4-yl)piperazine | HCID 795707 | — |
| Reactant | 5-Fluoro-2-nitroanisole | HCID 2779250 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine | HCID 56777249 | — |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
Into a 5 mL microwave tube was charged 4-fluoro-2-methoxy-1-nitrobenzene (0.1 g, 0.584 mmol), 1-methyl-4-(piperidin-4-yl)piperazine (0.321 g, 1.753 mmol), triethylamine (0.244 ml, 1.753 mmol), and acetonitrile (1.948 ml). The reaction was heated in Biotage microwave reactor at 130° C. for 40 minutes. The solvent was removed under reduced pressure, and the reaction purified by flash chromatography using a gradient 100% CH2Cl2 to 1:1 CH2Cl2/methanol to provide the title compound. MS (ESI) m/e 335 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354422B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-9f2d7a2b00e645608a2323b96bf92582 |
| Source note | uspto-grants-2013_01 |