N,N-Dimethylglycine → HCID 54321913, compound

Participants

Reaction Steps

A 100 mL round bottom flask with stirbar was charged with tert-butyl 4-aminophenylcarbamate (2.38 g, 11.43 mmol), 2-(dimethylamino)acetic acid (1.25 g, 12.12 mmol), 1-ethyl-3-[3-(dimethylamino)propyl]-carbodiimide hydrochloride (2.59 g, 13.51 mmol) and 4-dimethylaminopyridine (0.05 g, 0.409 mmol) in dichloromethane (50 ml). The solution was stirred at ambient temperature for 2 hours. The mixture was shaken in a separatory funnel with 50 mL aqueous sodium bicarbonate, and the organics were separated and dried over magnesium sulfate and filtered. Solvent removal gave the title compound. MS (ESI(+)) m/e 294.0 (M+H)+.

Provenance & Evidence