Water → HCID 24904659, compound

Participants

Reaction Steps

A 25 mL round bottom was charged with 1-(bromomethyl)-3-nitrobenzene (542 mg, 2.509 mmol) pyrrolidin-3-ol (0.813 mL, 10.04 mmol), and triethylamine (1.399 mL, 10.04 mmol) in acetonitrile (5 mL). The resulting solution was stirred overnight at ambient temperature then poured into water (150 mL) and extracted with CH2Cl2 (4×30 mL). The extracts were washed with sat. NaHCO3 solution, H2O and brine. The organic layer was then dried (Na2SO4) and concentrated in vacuo, yielding the title compound. MS (ESI(+)) m/e 222.9 (M+H)+.

Provenance & Evidence