Sulfuric Acid → HCID 54595612, compound

HRID 1804713Notes

Reaction equation

HRID 1804713 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]2[N:8]([CH:9]=1)[CH:7]=[CH:6][S:5]2.S(=O)(=O)(O)O.[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[Cl:1][C:2]1[N:3]=[C:4]2[N:8]([C:9]=1[C:15](=[O:17])[CH3:16])[CH:7]=[CH:6][S:5]2

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 7215826-Chloroimidazo[2,1-b]thiazole

Product 1

HCID 54595612HCID 54595612, compound

Conditions

Temperature
140 °C

Procedure

To a solution of 6-chloroimidazo[2,1-b]thiazole (7.93 g, 50 mmol) in acetic anhydride (150 mL) was added 0.2 ml of concentrated sulfuric acid. The mixture was stirred at 140° C. for 4 hours. The mixture was evaporated to dryness and the residue was taken up in water (300 mL), and the pH adjusted to pH ˜10 with aqueous NaOH. The resulting precipitate was filtered, washed with water and vacuum dried, providing the title compound. MS: (ESI(+)) m/e 200.8 (M+H)+.

Workup

  1. customThe mixture was evaporated to dryness
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with water and vacuum
  4. customdried

Sources & evidence

ORD record
ord-87a37c9ee04a43b0b9b42f63007a2cc5
Source dataset
uspto-grants-2013_01
Patent number
US08354422B2

Reaction notes

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