Azane;hydrate → HCID 59510742, compound

Participants

Reaction Steps

To a solution of 314 g of 5-(2-chloroethoxy)-2-((tetrahydro-2H-pyran-2-yloxy)methyl)-4H-pyran-4-one in 630 mL of methanol, 6.3 mL of concentrated hydrochloric acid was added and the mixture was stirred for 6 hours at room temperature. To the reaction mixture, 13 mL of 28% ammonia water was added and the solvent was evaporated under reduced pressure to give 240 g of 5-(2-chloroethoxy)-2-(hydroxymethyl)-4H-pyran-4-one (crude product) as a brown oily substance.

Provenance & Evidence