(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methanol → 2,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde

Participants

Reaction Conditions

Reaction Steps

To a solution of 111 g of (2,3-dihydro-(1,4)dioxino(2,3-c)pyridin-7-yl)methanol in 1110 mL of tetrahydrofuran, 164 g of manganese dioxide was added, the mixture was stirred for 5 hours at 70° C. and stirred overnight at room temperature. The reaction mixture was subjected to celite filtration and the filter residue was washed with 500 mL of tetrahydrofuran. The filtrate and the wash liquid were combined to evaporate the solvent under reduced pressure. The obtained residue was recrystallized from 750 mL of 2-propanol to give 53.5 g of 2,3-dihydro-(1,4)dioxino(2,3-c)pyridin-7-carbaldehyde as a light yellow solid.

Provenance & Evidence