Hydrochloric Acid → HCID 68673728, compound

Participants

Reaction Steps

A solution of 3.0 g of 2,3-dihydro-(1,4)dioxino(2,3-c)pyridin-7-carbaldehyde and 3.4 g of 4-amino-1-benzylpiperidine in 30 mL of methanol was stirred for 50 minutes at room temperature, and a solution of 0.34 g of sodium borohydride in 30 mL of 0.01 mol/L sodium hydroxide/methanol was added dropwise thereto under ice cooling. The mixture was further stirred for 2 hours under ice cooling, 6 mL of concentrated hydrochloric acid was added dropwise thereto at 10° C. or lower and stirred for 1 hour 30 minutes. The solid product was obtained by filtration to give 6.8 g of 1-benzyl-N-(2,3-dihydro-(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)piperidin-4-amine trihydrochloride as a white solid.

Provenance & Evidence