Hydrochloric Acid → (7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)acetaldehyde hydrochloride monohydrate

Participants

Reaction Conditions

Reaction Steps

To 480 mL of 2-butanone, 30 mL of 12 mol/L hydrochloric acid was added, the mixture was heated to 70° C. and a solution of 60 g of 1-(2,2-diethoxyethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one in 60 mL of 2-butanone was added dropwise, followed by reflux for 2 hours. After cooling the reaction mixture to 25° C., the solid product was obtained by filtration and washed with 2-butanone to give 50.3 g of (7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)acetaldehyde hydrochloride monohydrate as a light yellow solid.

Provenance & Evidence