Water → HCID 66845878, compound

Participants

Reaction Steps

A solution of 1.3 g (4.25 mmol) of 5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylic acid chloride, prepared in the preceding step, 2.1 mL (14.9 mmol) of triethylamine and 1.45 (4.68 mmol) of 5-amino-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine dihydrobromide (US 2005/256 125) in 42.5 mL of dichloromethane is stirred for 24 hours at room temperature. After this time, the mixture is poured into 200 mL of water. 100 mL of dichloromethane are added and the organic phase is then separated out, washed with twice 50 mL of water and concentrated under reduced pressure. The product obtained is purified by chromatography on a column of silica, eluting with a mixture of ethyl acetate and dichloromethane. The product thus purified is taken up in 100 mL of hot methanol, and the resulting suspension is filtered. The filtrate is concentrated under reduced pressure, thus allowing 0.4 g of the expected product to be isolated.

Provenance & Evidence