3-Methylbenzyl alcohol → Ethyl 6-trimethylsilyl-1-[(3-methylphenyl)methyl]-1H-indole-2-carboxylate

Participants

Reaction Steps

This compound was prepared according to a process similar to that described in step 5.1 by reacting ethyl 6-trimethylsilyl-1H-indole-2-carboxylate prepared according to the process described in step 9.2 with (3-methylphenyl)methanol in the presence of (cyanomethylene)tributylphosphorane (CMBP). The crude reaction product is then purified by flash chromatography on a column of silica gel to give the expected product.

Provenance & Evidence