反应详情

温度

80 °C

[2-(1-Benzenesulfonyl-cyclohex-2-enyl)-ethoxymethyl]-benzene (8) (16 g, 44.9 mmol) is dissolved in tert. butanol (450 ml) and after addition of potassium tert.-butoxide (11.1 g, 98.7 mmol) the mixture is stirred for 32 h at 80° C. Then the mixture is poured on ice and extracted with pentane. The organic layer is separated, washed with saturated NaCl-solution and dried over Na2SO4. The crude product is purified by Flash-chromatography (ethyl acetate/hexanes (1:9), silicagel).

1. additionThen the mixture is poured on ice
2. extractionextracted with pentane
3. customThe organic layer is separated
4. washwashed with saturated NaCl-solution
5. dry with materialdried over Na2SO4
6. customThe crude product is purified by Flash-chromatography (ethyl acetate/hexanes (1:9), silicagel)