反应详情

温度

100 °C

(1S,4S)-1-{2-[(3S,4S)-4-(2,2-Dimethyl-propionyloxy)-3-methyl-piperidin-1-yl]-ethyl}-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid tert-butyl ester (12) (880 mg, 2 mmol) is dissolved in 20 ml of water and after addition of concentrated aqueous HCl (38%, 1.2 ml) the mixture is stirred for 16 h at 100° C. Then the mixture is evaporated to dryness. The residue s treated three times with methanol and evaporated under educed pressure. The residue is diluted with ethyl acetate, extracted with 2M K2CO3, dried over Na2SO4 and evaporated under reduced pressure. The product was used in the next step without further purification.

1. customThen the mixture is evaporated to dryness
2. additionThe residue s treated three times with methanol
3. customevaporated under educed pressure
4. additionThe residue is diluted with ethyl acetate
5. extractionextracted with 2M K2CO3
6. dry with materialdried over Na2SO4
7. customevaporated under reduced pressure
8. customThe product was used in the next step without further purification