反应详情

10% Pd—C (240 mg) is placed into a round-bottom flask under an argon atmosphere and covered with methanol. A solution of (3S,4S)-3-Methyl-1-[2-(2-oxa-3-aza-bicyclo[2.2.2]oct-1-yl)-ethyl]-piperidin-4-ol (13) (584 mg, 2.3 mmol) in 20 ml of methanol is added and the mixture is hydrogenated for 2 h at room temperature. Then the mixture is filtrated over celite and evaporated under reduced pressure. The product was used in the next step without further purification.

1. filtrationThen the mixture is filtrated over celite
2. customevaporated under reduced pressure
3. customThe product was used in the next step without further purification