反应详情

The 4-cyclobutylmethoxy-1H-indole-2-carboxylic acid ethyl ester (15a) obtained above is mixed with a 2M-solution of KOH in EtOH (16.9 ml, 33.8 mmol) and stirred for 24 hours. The solvent is then evaporated and the residue is partitioned between water and DCM. The water layer is acidified with HCl and extracted twice with EtOAc. The combined organic layers are washed with brine, dried over anhydrous sodium sulfate, filtered and evaporated to give a white powder.

1. customThe solvent is then evaporated
2. customthe residue is partitioned between water and DCM
3. extractionextracted twice with EtOAc
4. washThe combined organic layers are washed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationfiltered
7. customevaporated
8. customto give a white powder