Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804773Generated: October 31, 2026

3-(Hydroxymethyl)-4,5,6,7-tetrahydro-1-benzofuran-4-one → 4-(4-Oxo-4,5,6,7-tetrahydro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid

https://huagongshe.com/reaction/1804773

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Hydroxymethyl)-4,5,6,7-tetrahydro-1-benzofuran-4-oneHCID 10855844—
ReactantEthyl 4-hydroxy-1H-indole-2-carboxylateHCID 13274763—
Reactant4-Cyclobutylmethoxy-1H-indole-2-carboxylic acidHCID 59152682—
Product4-(4-Oxo-4,5,6,7-tetrahydro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acidHCID 59152685—

Reaction Steps

4-(4-Oxo-4,5,6,7-tetrahydro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid (16f) is synthesized analogous to 16a from 4-oxo-4,5,6,7-tetrahydro-benzofuran-3-ylmethanol and 4-hydroxy-1H-indole-2-carboxylic acid ethyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354431B2
Source datasetuspto-grants-2013_01
ORD IDord-a33346fef56f41eab861d78fb6a51228
Source noteuspto-grants-2013_01