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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804780Generated: October 31, 2026

Ethyl 4-hydroxy-1H-indole-2-carboxylate → 4-[2-(2-methoxy-pyridin-3-yl)-ethoxy]-1H-indole-2-carboxylic acid

https://huagongshe.com/reaction/1804780

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 4-hydroxy-1H-indole-2-carboxylateHCID 13274763—
Reactant2-(2-Methoxy-3-pyridinyl)ethanolHCID 14062308—
Reactant4-Cyclobutylmethoxy-1H-indole-2-carboxylic acidHCID 59152682—
Product4-[2-(2-methoxy-pyridin-3-yl)-ethoxy]-1H-indole-2-carboxylic acidHCID 59152671—

Reaction Steps

4-[2-(2-Methoxy-pyridin-3-yl)-ethoxy]-1H-indole-2-carboxylic acid (16m) is synthesized analogous to 16a from 4-[2-(2-methoxy-pyridin-3-yl)-ethanol and 4-hydroxy-1H-indole-2-carboxylic acid ethyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354431B2
Source datasetuspto-grants-2013_01
ORD IDord-ba1cc8fe6d974b04afcf6350462f6eb9
Source noteuspto-grants-2013_01