Ethyl 4-hydroxy-1H-indole-2-carboxylate → HCID 59152649, compound

HRID 1804781Notes

Reaction equation

HRID 1804781 reaction equation
[CH:1]1([CH2:5][O:6][C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH:9]=[C:10]([C:16]([OH:18])=[O:17])[NH:11]3)[CH2:4][CH2:3][CH2:2]1.[CH3:19][O:20][C:21]1[N:26]=[CH:25]C(CCO)=CC=1.C(OC(C1NC2C(C=1)=C(O)C=CC=2)=O)C>>[CH3:19][O:20][C:21]1[N:26]=[CH:25][C:4]([CH2:1][CH2:5][O:6][C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH:9]=[C:10]([C:16]([OH:18])=[O:17])[NH:11]3)=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 13274763Ethyl 4-hydroxy-1H-indole-2-carboxylateHCID 220383673-Pyridineethanol,6-methoxy-(9CI)HCID 591526824-Cyclobutylmethoxy-1H-indole-2-carboxylic acid

Product 1

HCID 59152649HCID 59152649, compound

Procedure

4-[2-(6-Methoxy-pyridin-3-yl)-ethoxy]-1H-indole-2-carboxylic acid (16n) is synthesized analogous to 16a from 4-[2-(6-methoxy-pyridin-3-yl)-ethanol and 4-hydroxy-1H-indole-2-carboxylic acid ethyl ester.

Sources & evidence

ORD record
ord-82ef15143c464fa5bb11b53bb8efdf4a
Source dataset
uspto-grants-2013_01
Patent number
US08354431B2

Reaction notes

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