Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804782Generated: October 26, 2026

Ethyl 4-hydroxy-1H-indole-2-carboxylate → 4-[2-(6-methoxy-benzofuran-3-yl)-ethoxy]-1H-indole-2-carboxylic acid

https://huagongshe.com/reaction/1804782

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 4-hydroxy-1H-indole-2-carboxylateHCID 13274763—
Reactant2-(6-Methoxy-benzofuran-3-yl)ethanolHCID 23614444—
Reactant4-Cyclobutylmethoxy-1H-indole-2-carboxylic acidHCID 59152682—
Product4-[2-(6-methoxy-benzofuran-3-yl)-ethoxy]-1H-indole-2-carboxylic acidHCID 59152669—

Reaction Steps

4-[2-(6-methoxy-benzofuran-3-yl)-ethoxy]-1H-indole-2-carboxylic acid (16o) is synthesized analogous to 16a from 4-[2-(6-methoxy-benzofuran-3-yl)-ethanol 21 (synthesis see below) and 4-hydroxy-1H-indole-2-carboxylic acid ethyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354431B2
Source datasetuspto-grants-2013_01
ORD IDord-f4f1d8acbb9d4cde8ab8e2561e292d43
Source noteuspto-grants-2013_01