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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804794Generated: November 2, 2026

2-Bromoethyl ethyl ether → 4-[6-(2-Ethoxy-ethoxy)-benzofuran-3-ylmethoxy]-1H-indole-2-carboxylic acid

https://huagongshe.com/reaction/1804794

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromoethyl ethyl etherHCID 61141—
ReactantEthyl 6-hydroxybenzofuran-3-carboxylateHCID 59152646—
Reactant4-(6-Ethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acidHCID 59152664—
Product4-[6-(2-Ethoxy-ethoxy)-benzofuran-3-ylmethoxy]-1H-indole-2-carboxylic acidHCID 59152677—

Reaction Steps

4-[6-(2-Ethoxy-ethoxy)-benzofuran-3-ylmethoxy]-1H-indole-2-carboxylic acid (30c) is synthesized analogous to 30a from 6-hydroxy-benzofuran-3-carboxylic acid ethyl ester (26) and 2-bromoethyl ethyl ether.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354431B2
Source datasetuspto-grants-2013_01
ORD IDord-23d533680eeb492ea593c0391abf0b82
Source noteuspto-grants-2013_01