HCID 59152645, compound → 4-(Tetrahydro-furan-3-ylmethoxy)-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

HRID 1804796Notes

Reaction equation

HRID 1804796 reaction equation
[O:1]1[CH2:5][CH2:4][CH:3]([CH2:6][O:7][C:8]2[CH:16]=[CH:15][CH:14]=[C:13]3[C:9]=2[CH:10]=[C:11]([C:17]([OH:19])=O)[NH:12]3)[CH2:2]1.[NH2:20][CH:21]1[CH2:26][CH2:25][C:24]([CH2:28][CH2:29][N:30]2[CH2:35][CH2:34][C@H:33]([OH:36])[C@@H:32]([CH3:37])[CH2:31]2)([OH:27])[CH2:23][CH2:22]1>>[OH:27][C:24]1([CH2:28][CH2:29][N:30]2[CH2:35][CH2:34][C@H:33]([OH:36])[C@@H:32]([CH3:37])[CH2:31]2)[CH2:25][CH2:26][CH:21]([NH:20][C:17]([C:11]2[NH:12][C:13]3[C:9]([CH:10]=2)=[C:8]([O:7][CH2:6][CH:3]2[CH2:4][CH2:5][O:1][CH2:2]2)[CH:16]=[CH:15][CH:14]=3)=[O:19])[CH2:22][CH2:23]1

Participants

3

Reactant 2

HCID 59152645HCID 59152645, compoundHCID 591526504-(Tetrahydro-furan-3-ylmethoxy)-1H-indole-2-carboxylic acid

Product 1

HCID 250051614-(Tetrahydro-furan-3-ylmethoxy)-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-(tetrahydro-furan-3-ylmethoxy)-1H-indole-2-carboxylic acid 16b and amine 14.

Sources & evidence

ORD record
ord-69dd07b2428d4e0e81a38143d8d60ef9
Source dataset
uspto-grants-2013_01
Patent number
US08354431B2

Reaction notes

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