HCID 59152645, compound → 4-(2-Chloro-thiazol-4-ylmethoxy)-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

HRID 1804797Notes

Reaction equation

HRID 1804797 reaction equation
[Cl:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][O:8][C:9]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:10]=2[CH:11]=[C:12]([C:18]([OH:20])=O)[NH:13]3)[N:6]=1.[NH2:21][CH:22]1[CH2:27][CH2:26][C:25]([CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][C@H:34]([OH:37])[C@@H:33]([CH3:38])[CH2:32]2)([OH:28])[CH2:24][CH2:23]1>>[OH:28][C:25]1([CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][C@H:34]([OH:37])[C@@H:33]([CH3:38])[CH2:32]2)[CH2:26][CH2:27][CH:22]([NH:21][C:18]([C:12]2[NH:13][C:14]3[C:10]([CH:11]=2)=[C:9]([O:8][CH2:7][C:5]2[N:6]=[C:2]([Cl:1])[S:3][CH:4]=2)[CH:17]=[CH:16][CH:15]=3)=[O:20])[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 59152645HCID 59152645, compoundHCID 591526624-(2-Chloro-thiazol-4-ylmethoxy)-1H-indole-2-carboxylic acid

Product 1

HCID 250048214-(2-Chloro-thiazol-4-ylmethoxy)-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-(2-chloro-thiazol-4-ylmethoxy)-1H-indole-2-carboxylic acid 16d and amine 14.

Sources & evidence

ORD record
ord-7704fc98635a4d3da1236e5c0fbaf78a
Source dataset
uspto-grants-2013_01
Patent number
US08354431B2

Reaction notes

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