HCID 59152645, compound → 4-(6-Methoxy-pyridin-3-ylmethoxy)-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

HRID 1804798Notes

Reaction equation

HRID 1804798 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH2:9][O:10][C:11]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:12]=2[CH:13]=[C:14]([C:20]([OH:22])=O)[NH:15]3)=[CH:5][CH:4]=1.[NH2:23][CH:24]1[CH2:29][CH2:28][C:27]([CH2:31][CH2:32][N:33]2[CH2:38][CH2:37][C@H:36]([OH:39])[C@@H:35]([CH3:40])[CH2:34]2)([OH:30])[CH2:26][CH2:25]1>>[OH:30][C:27]1([CH2:31][CH2:32][N:33]2[CH2:38][CH2:37][C@H:36]([OH:39])[C@@H:35]([CH3:40])[CH2:34]2)[CH2:28][CH2:29][CH:24]([NH:23][C:20]([C:14]2[NH:15][C:16]3[C:12]([CH:13]=2)=[C:11]([O:10][CH2:9][C:6]2[CH:7]=[N:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH:19]=[CH:18][CH:17]=3)=[O:22])[CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 59152645HCID 59152645, compoundHCID 59152679HCID 59152679, compound

Product 1

HCID 250048204-(6-Methoxy-pyridin-3-ylmethoxy)-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-(6-methoxy-pyridin-3-ylmethoxy)-1H-indole-2-carboxylic acid 16e and amine 14.

Sources & evidence

ORD record
ord-4b1a00bba27b43e38ddd407e87483885
Source dataset
uspto-grants-2013_01
Patent number
US08354431B2

Reaction notes

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