HCID 59152645, compound → 4-[(S)-1-(2,3-Dihydro-benzofuran-3-yl)methoxy]-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

HRID 1804801Notes

Reaction equation

HRID 1804801 reaction equation
C[C:2]1(C)[CH2:24][C:23](=O)[C:5]2[C:6]([CH2:9][O:10][C:11]3[CH:19]=[CH:18][CH:17]=[C:16]4[C:12]=3[CH:13]=[C:14]([C:20](O)=[O:21])[NH:15]4)=[CH:7][O:8][C:4]=2[CH2:3]1.[NH2:27][CH:28]1[CH2:33][CH2:32][C:31]([CH2:35][CH2:36][N:37]2[CH2:42][CH2:41][C@H:40]([OH:43])[C@@H:39]([CH3:44])[CH2:38]2)([OH:34])[CH2:30][CH2:29]1>>[OH:34][C:31]1([CH2:35][CH2:36][N:37]2[CH2:42][CH2:41][C@H:40]([OH:43])[C@@H:39]([CH3:44])[CH2:38]2)[CH2:30][CH2:29][CH:28]([NH:27][C:20]([C:14]2[NH:15][C:16]3[C:12]([CH:13]=2)=[C:11]([O:10][CH2:9][C@H:6]2[C:5]4[CH:23]=[CH:24][CH:2]=[CH:3][C:4]=4[O:8][CH2:7]2)[CH:19]=[CH:18][CH:17]=3)=[O:21])[CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 59152645HCID 59152645, compoundHCID 591526864-(6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid

Product 1

HCID 250044904-[(S)-1-(2,3-Dihydro-benzofuran-3-yl)methoxy]-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-[(S)-1-(2,3-dihydro-benzofuran-3-yl)methoxy]-1H-indole-2-carboxylic acid 16h and amine 14.

Sources & evidence

ORD record
ord-7c85276077614ae284979e0137107ff8
Source dataset
uspto-grants-2013_01
Patent number
US08354431B2

Reaction notes

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