HCID 59152645, compound → 4-(4-Methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

HRID 1804802Notes

Reaction equation

HRID 1804802 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[C:9]([CH2:12][O:13][C:14]3[CH:22]=[CH:21][CH:20]=[C:19]4[C:15]=3[CH:16]=[C:17]([C:23]([OH:25])=O)[NH:18]4)=[CH:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.[NH2:26][CH:27]1[CH2:32][CH2:31][C:30]([CH2:34][CH2:35][N:36]2[CH2:41][CH2:40][C@H:39]([OH:42])[C@@H:38]([CH3:43])[CH2:37]2)([OH:33])[CH2:29][CH2:28]1>>[OH:33][C:30]1([CH2:34][CH2:35][N:36]2[CH2:41][CH2:40][C@H:39]([OH:42])[C@@H:38]([CH3:43])[CH2:37]2)[CH2:31][CH2:32][CH:27]([NH:26][C:23]([C:17]2[NH:18][C:19]3[C:15]([CH:16]=2)=[C:14]([O:13][CH2:12][C:9]2[C:8]4[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[CH:6][C:7]=4[O:11][CH:10]=2)[CH:22]=[CH:21][CH:20]=3)=[O:25])[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 59152645HCID 59152645, compoundHCID 668413694-(4-methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid

Product 1

HCID 250044884-(4-Methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-(4-methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid (synthesis described in WO2005077932A2, cmpd 122) and amine 14.

Sources & evidence

ORD record
ord-b411c9fe5aed40eaabff1afd3b1486dd
Source dataset
uspto-grants-2013_01
Patent number
US08354431B2

Reaction notes

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