HCID 59152645, compound → 4-(6-Cyclopropylmethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

HRID 1804807Notes

Reaction equation

HRID 1804807 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:28]=[CH:27][C:9]3[C:10]([CH2:13][O:14][C:15]4[CH:23]=[CH:22][CH:21]=[C:20]5[C:16]=4[CH:17]=[C:18]([C:24](O)=[O:25])[NH:19]5)=[CH:11][O:12][C:8]=3[CH:7]=2)[CH2:3][CH2:2]1.[NH2:29][CH:30]1[CH2:35][CH2:34][C:33]([CH2:37][CH2:38][N:39]2[CH2:44][CH2:43][C@H:42]([OH:45])[C@@H:41]([CH3:46])[CH2:40]2)([OH:36])[CH2:32][CH2:31]1>>[OH:36][C:33]1([CH2:37][CH2:38][N:39]2[CH2:44][CH2:43][C@H:42]([OH:45])[C@@H:41]([CH3:46])[CH2:40]2)[CH2:34][CH2:35][CH:30]([NH:29][C:24]([C:18]2[NH:19][C:20]3[C:16]([CH:17]=2)=[C:15]([O:14][CH2:13][C:10]2[C:9]4[CH:27]=[CH:28][C:6]([O:5][CH2:4][CH:1]5[CH2:2][CH2:3]5)=[CH:7][C:8]=4[O:12][CH:11]=2)[CH:23]=[CH:22][CH:21]=3)=[O:25])[CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 59152645HCID 59152645, compoundHCID 59152656HCID 59152656, compound

Product 1

HCID 250058864-(6-Cyclopropylmethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-(6-cyclopropylmethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid 30b and amine 14.

Sources & evidence

ORD record
ord-1239ff2f808c437196be51a0c385f1eb
Source dataset
uspto-grants-2013_01
Patent number
US08354431B2

Reaction notes

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