HCID 59152645, compound → 4-[2-(3-Methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

HRID 1804815Notes

Reaction equation

HRID 1804815 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][O:11][C:12]2[CH:20]=[CH:19][CH:18]=[C:17]3[C:13]=2[CH:14]=[C:15]([C:21]([OH:23])=O)[NH:16]3)[CH:6]=[CH:7][CH:8]=1.[NH2:24][CH:25]1[CH2:30][CH2:29][C:28]([CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][C@H:37]([OH:40])[C@@H:36]([CH3:41])[CH2:35]2)([OH:31])[CH2:27][CH2:26]1>>[OH:31][C:28]1([CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][C@H:37]([OH:40])[C@@H:36]([CH3:41])[CH2:35]2)[CH2:29][CH2:30][CH:25]([NH:24][C:21]([C:15]2[NH:16][C:17]3[C:13]([CH:14]=2)=[C:12]([O:11][CH2:10][CH2:9][C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH:20]=[CH:19][CH:18]=3)=[O:23])[CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 59152645HCID 59152645, compoundHCID 59152678HCID 59152678, compound

Product 1

HCID 250066364-[2-(3-Methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-[2-(3-methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid 16k and amine 14.

Sources & evidence

ORD record
ord-ec17fb578b5a4383964717e979aa2c6d
Source dataset
uspto-grants-2013_01
Patent number
US08354431B2

Reaction notes

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