HCID 59152645, compound → 4-[2-(4-Methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

HRID 1804816Notes

Reaction equation

HRID 1804816 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][O:11][C:12]2[CH:20]=[CH:19][CH:18]=[C:17]3[C:13]=2[CH:14]=[C:15]([C:21]([OH:23])=O)[NH:16]3)=[CH:5][CH:4]=1.[NH2:24][CH:25]1[CH2:30][CH2:29][C:28]([CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][C@H:37]([OH:40])[C@@H:36]([CH3:41])[CH2:35]2)([OH:31])[CH2:27][CH2:26]1>>[OH:31][C:28]1([CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][C@H:37]([OH:40])[C@@H:36]([CH3:41])[CH2:35]2)[CH2:29][CH2:30][CH:25]([NH:24][C:21]([C:15]2[NH:16][C:17]3[C:13]([CH:14]=2)=[C:12]([O:11][CH2:10][CH2:9][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[CH:20]=[CH:19][CH:18]=3)=[O:23])[CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 59152645HCID 59152645, compoundHCID 59152665HCID 59152665, compound

Product 1

HCID 250062614-[2-(4-Methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-[2-(4-methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid 161 and amine 14.

Sources & evidence

ORD record
ord-cff24497ed9947f8b2c13da48df8d27a
Source dataset
uspto-grants-2013_01
Patent number
US08354431B2

Reaction notes

Loading…