HCID 59152645, compound → 4-[2-(6-Methoxy-benzofuran-3-yl)-ethoxy]-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

HRID 1804819Notes

Reaction equation

HRID 1804819 reaction equation
[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:6]2[C:7]([CH2:10][CH2:11][O:12][C:13]3[CH:21]=[CH:20][CH:19]=[C:18]4[C:14]=3[CH:15]=[C:16]([C:22]([OH:24])=O)[NH:17]4)=[CH:8][O:9][C:5]=2[CH:4]=1.[NH2:27][CH:28]1[CH2:33][CH2:32][C:31]([CH2:35][CH2:36][N:37]2[CH2:42][CH2:41][C@H:40]([OH:43])[C@@H:39]([CH3:44])[CH2:38]2)([OH:34])[CH2:30][CH2:29]1>>[OH:34][C:31]1([CH2:35][CH2:36][N:37]2[CH2:42][CH2:41][C@H:40]([OH:43])[C@@H:39]([CH3:44])[CH2:38]2)[CH2:32][CH2:33][CH:28]([NH:27][C:22]([C:16]2[NH:17][C:18]3[C:14]([CH:15]=2)=[C:13]([O:12][CH2:11][CH2:10][C:7]2[C:6]4[CH:25]=[CH:26][C:3]([O:2][CH3:1])=[CH:4][C:5]=4[O:9][CH:8]=2)[CH:21]=[CH:20][CH:19]=3)=[O:24])[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 59152645HCID 59152645, compoundHCID 591526694-[2-(6-methoxy-benzofuran-3-yl)-ethoxy]-1H-indole-2-carboxylic acid

Product 1

HCID 250062584-[2-(6-Methoxy-benzofuran-3-yl)-ethoxy]-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-[2-(6-methoxy-benzofuran-3-yl)-ethoxy]-1H-indole-2-carboxylic acid 16o and amine 14.

Sources & evidence

ORD record
ord-969120c2015c445085b9c763b56bc5a8
Source dataset
uspto-grants-2013_01
Patent number
US08354431B2

Reaction notes

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