O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 67334241, compound

Participants

Reaction Steps

To a stirred solution of Example 1, A2 in DMF (0.3 M) was added TEA (2.4 eq.) and TBTU (1.3 eq.). The mixture was stirred for 20 min and tent-butyl piperazine-1-carboxylate was added (1.5 eq.). After 1 h the mixture was diluted with EtOAc and washed with water, s.s. NaHCO3 and brine. The organic phase was dried over Na2SO4, filtered and concentrated to dryness to afford the title compound as an orange foam.

Provenance & Evidence