Isopropyl iodide → HCID 86639800, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-1-(1-(2,4-dichloro-5-hydroxyphenyl)piperidin-4-yl)ethanone (30 mg, 0.064 mmol) in anhydrous acetonitrile (1.5 mL) was treated with 2-iodopropane (0.019 mL, 0.191 mmol) and cesium carbonate (41.5 mg, 0.127 mmol) and the mixture stirred at 50° C. for 1 h. After this time, the mixture was concentrated on a rotary evaporator and the resultant residue was partitioned between water and EtOAc. The EtOAc phase was washed with brine, dried (MgSO4) and concentrated to give 2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-1-(1-(2,4-dichloro-5-isopropoxyphenyl)piperidin-4-yl)ethanone. LC-MS: 512.20, [M+H]; tR=2.30 min (method a).

Provenance & Evidence