Methyl isonipecotate → HCID 68554599, compound

Participants

Reaction Steps

Methyl 1-(4-chloro-3-methoxyphenyl)piperidine-4-carboxylate was synthesized from 4-bromo-1-chloro-2-methoxybenzene and methyl piperidine-4-carboxylate analogous to the preparation described in Example 1a, Step 1. 1H-NMR (500 MHz, CDCl3) δ ppm 7.19 (1 H, d, J=8.57 Hz), 6.51 (1 H, s), 6.44 (1 H, s), 5.82 (1 H,), 3.85-3.88 (3 H, m), 3.70-3.72 (3 H, m), 3.33 (2 H, d, J=11.55 Hz), 2.67-2.74 (2 H, m), 2.46 (1 H, ddd, J=15.05, 10.52, 4.40 Hz), 1.94-2.04 (4 H, m).

Provenance & Evidence