Aluminium lithium hydride → HCID 68552870, compound

Participants

Reaction Steps

To a solution of ethyl 2-(1-(2,4-dichloro-5-methoxyphenyl)-4-hydroxypiperidin-4-yl)acetate (1 g, 2.76 mmol) in THF (10 mL) was added LiAlH4 (0.210 g, 5.52 mmol). The reaction mixture was stirred at RT for 2 h, quenched with minimum water and then treated with EtOAc and solid NaHCO3. The mixture was stirred and filtered. The filtrate was concentrated to give 1-(2,4-dichloro-5-methoxyphenyl)-4-(2-hydroxyethyl)piperidin-4-ol (0.62 g, 1.936 mmol, 70% yield) as a yellow oil.

Provenance & Evidence