Bromine → HCID 18511696, compound

HRID 1804868Notes

Reaction equation

HRID 1804868 reaction equation
[C:1]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[C:7]([O:15]C(=O)C)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br:19]Br>C(O)(=O)C>[BrH:19].[Br:19][CH2:2][C:1]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[C:7]([OH:15])=[CH:6][CH:5]=1)=[O:3]

Participants

4

Reactant 2

HCID 24408BromineHCID 15541469HCID 15541469, compound

Product 1

HCID 18511696HCID 18511696, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
75 °C

Procedure

To a solution of 0.88 g of 6-acetyl-3-acetyloxy-2-ethoxycarbonylpyridine in 8.8 ml of acetic acid was added 0.19 ml of bromine dropwise, and the mixture was stirred at 75° C. for 5 minutes. Evaporation of the solvent gave 0.77 g of 6-(2-bromoacetyl)-2-ethoxycarbonyl-3-hydroxypyridine hydrobromide.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-acce61671c3a4fefa1ddf6b44ffcc43f
Source dataset
uspto-grants-2013_01
Patent number
US08354439B2

Reaction notes

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