反应详情

To a suspension of 970 mg of 2-(4-methoxy-3-propoxyphenyl)-4-(5-methoxycarbonyl-2-furyl)thiazole in 30 ml of methanol was added 20 ml of 1,4-dioxane and 5 ml of a 5 N aqueous sodium hydroxide solution. The reaction mixture was refluxed for 3 hours, then concentrated approximately 1/10. Water was added to the residue, and washed with ethyl acetate. To the aqueous layer was acidified with 5 N hydrochloric acid, and extracted with ethyl acetate. The combined organic layer was washed with water and a saturated aqueous sodium chloride solution, and dried with magnesium sulfate. Evaporation the solution, the residue was recrystallized from ethyl acetate to obtain 420 mg of 2-(4-methoxy-3-propoxyphenyl)-4-(5-carbonyl-2-furyl)thiazole as a white powder. mp. 191.0-192.0° C.

1. temperatureThe reaction mixture was refluxed for 3 hours
2. concentrationconcentrated approximately 1/10
3. additionWater was added to the residue
4. washwashed with ethyl acetate
5. extractionextracted with ethyl acetate
6. washThe combined organic layer was washed with water
7. dry with materiala saturated aqueous sodium chloride solution, and dried with magnesium sulfate
8. customEvaporation the solution
9. customthe residue was recrystallized from ethyl acetate