N-(2-cyanoethyl)glycine → N-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)-N-(2-cyanoethyl)glycine
Reaction equation
[C:24](#[N:25])[CH2:26][CH2:27][NH:28][CH2:29][C:30](=[O:31])[OH:32].[Cl:1][c:2]1[c:3]([F:23])[c:4]([NH:5][c:6]2[n:7][cH:8][n:9][c:10]3[cH:11][c:12]([O:18][CH3:19])[c:13]([CH:16]=[O:17])[cH:14][c:15]23)[cH:20][cH:21][cH:22]1>>[Cl:1][c:2]1[c:3]([F:23])[c:4]([NH:5][c:6]2[n:7][cH:8][n:9][c:10]3[cH:11][c:12]([O:18][CH3:19])[c:13]([CH2:16][N:28]([CH2:27][CH2:26][C:24]#[N:25])[CH2:29][C:30](=[O:31])[OH:32])[cH:14][c:15]23)[cH:20][cH:21][cH:22]1Participants
3
Sources & evidence
- ORD record
- ord-464f631b39eb4a348cf8d1a9f4508d36
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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