5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid → HCID 44191632, compound

HRID 1805191Notes

Reaction equation

HRID 1805191 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([C:21](O)=O)[C:9]=2[CH3:24])=[CH:4][CH:3]=1.[CH2:25]([NH:27][C:28]([CH3:33])([CH3:32])[C:29]([NH2:31])=[O:30])[CH3:26]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([C:21]3[N:27]([CH2:25][CH3:26])[C:28]([CH3:33])([CH3:32])[C:29](=[O:30])[N:31]=3)[C:9]=2[CH3:24])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 15194215-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acidHCID 18792211HCID 18792211, compound

Product 1

HCID 44191632HCID 44191632, compound

Procedure

Compound 7 was synthesized from 4a (251 mg, 0.66 mmol) and 5b (140 mg, 1.08 mmol) as a white solid (110 mg, 35%) in a manner similar to that described in Example 36. 1H NMR (400 MHz, CDCl3) δ 7.43 (d, 1H), 7.28 (d, 2H), 7.25 (dd, H), 7.14 (d, 1H), 7.04 (d, 2H), 3.90 (q, 2H), 2.37 (s, 3H), 1.41 (s, 6H), 1.27 (t, 3H); ESMS m/z: 475.0 (M+1).

Sources & evidence

ORD record
ord-42baf147b12b46d28f9ee775b3ac6096
Source dataset
uspto-grants-2013_01
Patent number
US08354442B2

Reaction notes

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