5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid → 2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-one

Participants

Role	Name	HCID	Charge
Reactant	5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid	HCID 1477240	—
Reactant	2-Methyl-2-(methylamino)propanamide	HCID 18682977	—
Product	2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-one	HCID 44191808	—

Reaction Steps

Compound 14 was synthesized from 4b (249 mg, 0.68 mmol) and 5a (130 mg, 1.08 mmol) as a white solid (152 mg, 49%) in a manner similar to that described in Example 36. 1H NMR (400 MHz, CDCl3) δ 7.45 (d, 1H), 7.30-7.28 (m, 3H), 7.21 (d, 2H), 7.04 (d, 2H), 3.48 (s, 3H), 1.36 (s, 6H); ESMS m/z: 447.0 (M+1)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354442B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-4992c8a2a09d49349eedce3acd20874e
Source note	uspto-grants-2013_01